Is Familial Hyperaldosteronism Underdiagnosed in Hypertensive Children?
نویسندگان
چکیده
منابع مشابه
Editorial Commentary Is Familial Hyperaldosteronism Underdiagnosed in Hypertensive Children?
Primary aldosteronism (PA) is the most frequent cause of secondary hypertension in adults, accounting for 5% to 15% of hypertensive patients, depending on the severity of blood pressure levels.1,2 Patients with PA undergo a higher rate of cardiovascular complications compared with essential hypertensives, and, thus, the screening of hypertensive subgroups of patients with higher prevalence of P...
متن کاملFamilial hyperaldosteronism.
Aldosterone, the major circulating mineralocorticoid, participates in blood volume and serum potassium homeostasis. Primary aldosteronism is a disorder characterised by hypertension and hypokalaemia due to autonomous aldosterone secretion from the adrenocortical zona glomerulosa. Improved screening techniques, particularly application of the plasma aldosterone:plasma renin activity ratio, have ...
متن کاملFamilial hypercholesterolaemia: underdiagnosed and undertreated.
Autosomal dominant familial hypercholesterolaemia (FH) is the most common inherited disorder known to cause premature coronary heart disease in people of European descent. The estimated prevalence of FH is 1 in 500, and heterozygous FH carries a high risk of premature coronary disease if left untreated (.50% risk in men by the age of 50 and .30% in women by 60 years). However, the condition is ...
متن کاملAn Update on Familial Hyperaldosteronism
▼ Familial forms of primary aldosteronism have been suggested to account for up to 6 % of cases in referral centers. For many years, the genetics of familial hyperaldosteronism remained unknown, with the notable exception of glucocorticoid-remediable aldosteronism, due to unequal crossing over and formation of a chimeric 11β-hydroxylase/ aldosterone synthase gene. Over the past 5 years, mutatio...
متن کاملAn Update on Familial Hyperaldosteronism
▼ Familial forms of primary aldosteronism have been suggested to account for up to 6 % of cases in referral centers. For many years, the genetics of familial hyperaldosteronism remained unknown, with the notable exception of glucocorticoid-remediable aldosteronism, due to unequal crossing over and formation of a chimeric 11β-hydroxylase/ aldosterone synthase gene. Over the past 5 years, mutatio...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2011
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.111.172916